Description of service

Luminex potency assay for cytokine/chemokine responses in human blood. LSHTM will provide an ex vivo whole-blood assay to compare the potency of vaccine candidates based on their ability to induce innate and adaptive cytokine and chemokine responses, detected by capturing the secreted proteins on customised or commercial Luminex bead arrays. This can be used to confirm the potency of vaccine candidates in a human immune system model, to compare different vaccines or the same vaccine produced in different expression hosts, or to ensure consistent production quality and batch-to-batch reproducibility, including of live whole cell vaccines. The service will be provided as units of access that enable testing of 35 supernatants in duplicate in addition to the necessary standards and biological controls.