Instruct-ERIC is a distributed European research infrastructure in structural biology, making high-end technologies and methods available to researchers. Instruct infrastructure provides the technical frameworks with which we can interpret molecular and cellular functions. The main experimental technologies that Instruct offers are complementary, and increasingly link detailed atomic structure of single molecules or macromolecular complexes with their cellular context. Instruct offers access to the full catalogue of services in the infrastructure, through a single entry point. It supports proposals that use different technologies to build up knowledge of functional mechanisms and intracellular dynamics with atomic structure information and integrate these into an understanding of cellular processes in the native environment and in real time.